How diet and the gut bacteria may point to new treatments for depression.

Worldwide, some 280 million people Trusted Source, or 5% of the adult population, have depression. The globe Health Organization has called it a “leading explanation for disability worldwide” Trusted Source. The currently available treatments like antidepressants and behavioral therapies are effective for several people but aren't suitable or available to any or all.

Some research has suggested that diet may have a control on depression. A diet high in processed foods Trusted Source has been linked to more severe symptoms, while eating more fresh, plant-based foods may decrease symptoms Trusted Source.

Now, a study, published in Cell Metabolism Trusted Source, suggests that the severity of depression could also be influenced by one specific aminoalkanoic acid — proline.

The research also indicates that a person’s gut bacteria may affect how that organic compound is processed, and the way it can counter its depressive effects in some people.

The researchers used a multi-omics Trusted Source approach to the analysis — an integrated analysis of the many different molecules.

First, they analyzed the sort and amount of amino acids within the diets of these participating within the study. They also analyzed plasma and fecal samples from the participants.

Those who had the next level of proline in their diet reported more severe depression.